Endocrine Abstracts

Background: Visceral obesity has been associated with systemic oxidative stress, measured by oxidized LDL (oxLDL).Aim: Investigate circulating oxLDL levels in patients with visceral obesity, and its relationship with metabolic abnormalities found in visceral obesity.Methods: We evaluated blood pressure (BP), waist circumference (WC), fasting glucose, total cholesterol, LDL, HDL, triglycerides, ApoA1, ApoB, ApoCIII, Lp(a) and oxLDL ...

Introduction: The new guidelines for the management of hypothyroidism (HP) during pregnancy recommend a tighter treatment with levothyroxine (Lt4) to reach TSH values similar to those of pregnant women without thyroid dysfunction (TSH <2.5 mU/l in the 1st trimester-T- and TSH <3mu/l in the 2nd and 3rd T).Objectives: To assess the degree of control of HP in women followed during pregnancy according to the current criteria and the possible associat...

Familial combined pituitary hormone deficiency can be due to a PROP 1 gene mutation. PROP1 is essential to pituitary morphogenesis. Mutations with inactivation of this gene results in deficiency of GH, PRL, TSH, LH, FSH and in some cases, ACTH.The authors describe an affected family, two sibs, with panhyopituitarism: a 10 years old female, and a 15 years old male, who presented with growth and pubertary development delay. Both children lacked GH, TSH, PR...

We report an 18-year-old boy referred to our outpatient clinic at 8 years and 11 months of age with a history of early-onset childhood hiperphagia, infantile central hipotonia and lethargy, mild mental retardation and emotional instability. His height was 125 cm, height SDS = -1 (target height = 169,5 cm, SDS = -0,78) and he weighted 40 Kg (BMI = 25,6;WFH =164%). He had small hands and feet, fat face with prominent forehead, bitemporal narrowing, triangular upper lip, microgna...

Background: The screening of patients and relatives for the presence of inactivating mutations of the MEN 1 gene, established quite accurately those for prospective detection of neoplasms. Active search for pancreatic lesions has increased the detection of neuroendocrine pancreatic tumours (NEPT) at early ages, most asymptomatic and with no signs of malignancy at diagnosis.Case Report: We describe one kindred where five members were identified as carrier...

Background: Semaglutide is a glucagon-like peptide-1 receptor agonist (GLP-1-RA) whose role as a second-line treatment for patients with type 2 diabetes (T2D) has significantly increased. It has demonstrated cardiovascular safety and superiority in terms of glycaemic control and weight loss, compared to other GLP-1-RAs. The most common side effects are mild gastrointestinal, but it may also cause renal failure secondary to dehydration and an increased risk of diabetic retinopa...

Introduction and objective: Neuroendocrine tumors (NETs) are relatively rare tumors. The majority are located in the gastrointestinal (GI) tract and bronchopulmonary system. The aim of this report is to study the characteristics of gastrointestinal NETs at diagnosis.Material and methods: Descriptive study about 18 patients diagnosed of gastrointestinal NETs during 1993–2011 in our hospital. Data regarding demographic, clinical, analytical, anatomopa...